The CMBI performs research in cheminformatics and in the molecular aspects of bioinformatics. This research is performed by the following groups:
- Huynen. Computational genomics. Whole genome comparisons.
The sequencing of complete genomes raises the question: how do we show that a genome is more than the sum of its genes?, or, how do the proteins encoded in these genomes interact with each other to produce cells and phenotypes? The core research focus of the Huynen group is to predict such functional interactions between proteins as there exist e.g. in metabolic pathways, signalling pathways or protein complexes.
- van Hijum. Bacterial genomics. Food bacteria.
Microorganisms such as yeasts, fungi and bacteria are used extensively in the preparation of foodstuffs. The carefully controlled use of food-grade bacteria plays an important role in starter cultures (mainly lactic acid bacteria) and in the production of specific metabolites and other ingredients. In addition, so-called 'probiotic' bacteria are added to some foods in an attempt to enhance human health. In contrast, any unintentional microbial contamination of food can adversely affect food safety and shelf-life.
- Computational drug design. Protein-ligand interactions.
Computational drug discovery is a well-established scientific discipline in pharmaceutical research, critical in the development of new treatments. It has created many opportunities to speed up and rationalise the multidisciplinary drug discovery process, and provide novel approaches to the design of drugs otherwise not possible.
- Vriend. Protein Structure Bioinformatics. Protein structure analysis and prediction. Data mining.
Proteins are the core of life, they do all the work, and they give you feelings, contact with the outside world, etc. Proteins, therefore, are the most important molecules on earth. We want to understand life; why are we what we are, why do we do what we do, how come you can think what you think? Therefore we must understand proteins and all our work is amimed at just that: understanding proteins. We want to use this understanding to improve the world around us in a careful and responsible manner